Product introduction
Zoryl M 1 Tablet PR is a fixed-dose combination medicine used in the management of type 2 diabetes mellitus. It brings together glimepiride, a sulfonylurea that stimulates the pancreas to release more insulin, with metformin, a biguanide that improves the body's response to insulin and reduces glucose output from the liver. This tablet is formulated in a prolonged-release (PR) form, which allows the medicine to be released gradually through the day. It is generally prescribed when diet, exercise and a single anti-diabetic medicine are not enough to keep blood sugar within the target range.
Storage: Store below 25°C, in a cool, dry place away from direct sunlight and moisture.
Uses of Zoryl M 1 Tablet PR
- Long-term management of type 2 diabetes mellitus
- Used alongside diet and exercise to control blood glucose levels
- Helps reduce the risk of diabetes-related complications such as kidney and nerve damage
Benefits of Zoryl M 1 Tablet PR
Works through two complementary mechanisms to bring blood glucose under control more effectively than a single medicine alone,Sustained glycaemic control may help lower the long-term risk of diabetes complications affecting the kidneys, eyes, nerves and heart,The prolonged-release formulation is designed to provide steadier blood sugar control across the day with once-daily dosing
Side effects of Zoryl M 1 Tablet PR
Most side effects do not require medical attention and go away as your body adjusts. Consult your doctor if they persist.
- Nausea
- Diarrhoea or loose motions
- Loss of appetite
- Low blood sugar (hypoglycaemia)
- Headache
- Change in taste sensation
How to use Zoryl M 1 Tablet PR
Take this tablet with or right after a meal, exactly as advised by your doctor,Swallow the tablet whole; do not crush, chew or break the prolonged-release tablet,Try to take it at the same time every day so blood levels of the medicine stay consistent
How Zoryl M 1 Tablet PR works
Glimepiride prompts the beta cells of the pancreas to secrete more insulin, helping move glucose out of the bloodstream and into cells,Metformin cuts down the amount of glucose the liver produces and makes muscle and fat cells more responsive to insulin,Together the two actions lower blood sugar from more than one direction, which can be more effective than either medicine used alone
Substitutes for Zoryl M 1 Tablet PR
These medicines have the same composition (Glimepiride (1mg) + Metformin (500mg)) and can generally be used as alternatives. Always confirm with your doctor or our pharmacist before switching.
Safety advice
Drinking alcohol with this medicine can increase the risk of low blood sugar and is best avoided.
Safety in pregnancy has not been established; use only if your doctor feels the benefit outweighs the risk.
It is not known if this medicine passes into breast milk, so a doctor's advice is needed before use while breastfeeding.
This medicine can occasionally cause low or high blood sugar, which may affect concentration; be cautious while driving.
This combination is not recommended for people with significant kidney impairment; dose adjustment or an alternative may be needed.
This medicine is not recommended for people with liver disease, as it may not be processed safely.
Quick tips
- Never skip a meal after taking this tablet, as it can cause your blood sugar to fall too low
- Keep a fast-acting sugar source handy in case you feel symptoms of low blood sugar such as sweating or shakiness
- Get your blood glucose and kidney function checked periodically as advised by your doctor
- Avoid alcohol, as it can increase the risk of low blood sugar and other side effects
- Do not stop the medicine on your own even if you feel well; diabetes needs continuous management
Fact box
| Chemical class | Not specified |
|---|---|
| Habit forming | No |
| Therapeutic class | Anti Diabetic |
| Action class | Oral Antidiabetics |
Frequently asked questions
Can I take Zoryl M 1 Tablet PR without food?
No, it should be taken with or right after a meal to reduce the chance of stomach upset and low blood sugar.
What should I do if I miss a dose?
Take it as soon as you remember, but skip the missed dose if it is almost time for the next one. Never take a double dose.
Is Zoryl M 1 Tablet PR a substitute for diet and exercise?
No, it works best alongside a controlled diet and regular physical activity, not as a replacement for them.
Can this medicine be used for type 1 diabetes?
No, it is intended for type 2 diabetes and is not suitable for type 1 diabetes.
How will I know if my blood sugar has dropped too low?
Watch for signs like sweating, shakiness, dizziness or confusion, and inform your doctor if these occur frequently.