Product introduction
Amaryl M 1mg Tablet PR is a prolonged-release combination medicine used to manage type 2 diabetes in adults. It brings together glimepiride, a sulfonylurea that nudges the pancreas to release more insulin, with metformin, a biguanide that helps the body use insulin more effectively. The prolonged-release formulation is designed to release metformin steadily through the day, which can mean fewer tablets are needed compared to immediate-release combinations. It is meant to be used together with a suitable diet and regular physical activity, not as a substitute for them.
Storage: Store below 25°C
Uses of Amaryl M 1mg Tablet PR
- Type 2 diabetes mellitus
- Blood sugar control alongside diet and exercise
- Used when metformin alone does not control blood sugar adequately
Benefits of Amaryl M 1mg Tablet PR
By combining two complementary mechanisms in a single tablet, this medicine can offer better blood sugar control than either component alone while simplifying a patient's daily dosing routine. The prolonged-release metformin component may also be gentler on the stomach for some patients compared to standard-release metformin taken multiple times a day.
Side effects of Amaryl M 1mg Tablet PR
Most side effects do not require medical attention and go away as your body adjusts. Consult your doctor if they persist.
- Headache
- Hypoglycemia (low blood sugar)
- Nausea
- Diarrhea
- Loss of appetite
How to use Amaryl M 1mg Tablet PR
This tablet is usually taken once daily with a meal, exactly as advised by the prescribing doctor, and should be swallowed whole without crushing or chewing so the prolonged-release effect is preserved. Dosage is individualized based on blood sugar readings, so it should never be adjusted without medical guidance.
How Amaryl M 1mg Tablet PR works
Glimepiride works by stimulating the beta cells of the pancreas to release more insulin, which helps move glucose out of the bloodstream and into cells. Metformin complements this by reducing the amount of glucose the liver produces and by improving how efficiently muscle and fat cells respond to insulin. Together, the two actions target blood sugar from multiple angles.
Substitutes for Amaryl M 1mg Tablet PR
These medicines have the same composition (Glimepiride (1mg) + Metformin (500mg)) and can generally be used as alternatives. Always confirm with your doctor or our pharmacist before switching.
Safety advice
Alcohol can increase the risk of low blood sugar and, rarely, a serious metabolic complication linked to metformin, so it is best limited or avoided.
This combination is not usually the first choice during pregnancy, and a doctor should decide on an appropriate diabetes treatment plan.
Whether this medicine is suitable while breastfeeding should be assessed by a doctor based on the infant's health and feeding pattern.
Low blood sugar episodes can cause dizziness or reduced alertness, so caution is advised when driving or operating machinery.
Dosing needs to be adjusted based on kidney function, and this medicine may not be suitable for patients with significant kidney impairment.
Patients with liver disease should use this medicine only under close medical supervision, as it can affect blood sugar regulation.
Quick tips
- Take the tablet with the same meal each day to keep blood sugar control consistent
- Do not skip meals after taking this medicine, as it can lead to low blood sugar
- Keep a fast-acting sugar source like glucose tablets or candy on hand in case of hypoglycemia symptoms
- Get kidney function checked periodically, since metformin dosing depends on it
- Avoid alcohol, as it can increase the risk of low blood sugar and other complications
Fact box
| Chemical class | Sulfonylurea and Biguanide combination |
|---|---|
| Habit forming | No |
| Therapeutic class | Anti Diabetic |
| Action class | Sulfonylureas and Biguanides combination |
Frequently asked questions
What is Amaryl M 1mg Tablet PR used for?
It is used to manage blood sugar levels in adults with type 2 diabetes, typically alongside a controlled diet and regular exercise.
Can I stop taking it once my sugar levels are normal?
No, it should not be stopped without a doctor's advice, since diabetes management is usually a long-term commitment and stopping suddenly can cause sugar levels to rise again.
What should I do if I miss a dose?
Take the missed dose as soon as remembered unless it is close to the next dose, in which case it is better to skip it rather than double up.
Can this tablet cause low blood sugar?
Yes, hypoglycemia is a known side effect, especially if meals are skipped or delayed, so recognizing symptoms like shakiness or sweating is important.
Is this tablet safe for people with kidney problems?
It needs careful evaluation by a doctor, as the metformin component requires dose adjustment or avoidance depending on the level of kidney function.