Product introduction
Glimestar PM2 Tablet ER is a three-drug, extended-release combination used in type 2 diabetes when a simpler two-drug regimen no longer keeps blood sugar in check. It brings together glimepiride, metformin, and pioglitazone, each working through a different route to lower glucose. Made by Mankind Pharma Ltd, the extended-release form is built to release the medicine gradually for steadier day-long control. It is prescribed only after a doctor evaluates that a triple combination is appropriate for the individual patient.
Storage: Store below 30°C in a cool, dry place, away from direct sunlight and moisture. Keep out of reach of children.
Uses of Glimestar PM2 Tablet ER
- Control of high blood sugar in type 2 diabetes
- Used for patients who need a three-way combination when dual therapy isn't sufficient
- Helps improve overall insulin sensitivity alongside diet and exercise
Benefits of Glimestar PM2 Tablet ER
Combines three complementary mechanisms for patients needing stronger glucose control,Extended-release formulation supports steady blood sugar levels with once-daily use,May help when dual-therapy combinations have not achieved adequate control
Side effects of Glimestar PM2 Tablet ER
Most side effects do not require medical attention and go away as your body adjusts. Consult your doctor if they persist.
- Headache
- Sinus inflammation
- Muscle pain
- Sore throat
- Upper respiratory tract infection
How to use Glimestar PM2 Tablet ER
Take with or after a meal, generally at the same time each day,Swallow the tablet whole with water; do not chew, crush, or break it,Do not skip meals after taking the dose, as this can increase the risk of low blood sugar
How Glimestar PM2 Tablet ER works
Glimepiride increases the amount of insulin released by the pancreas,Metformin lowers glucose production in the liver and improves insulin sensitivity,Pioglitazone further increases the body's sensitivity to insulin, helping cells use glucose more effectively; together the three actions provide broader glucose control
Substitutes for Glimestar PM2 Tablet ER
No other medicine with the same composition is listed in our catalogue yet. Message us on WhatsApp and our pharmacist will help you find a suitable alternative.
Safety advice
Drinking alcohol with this medicine is not recommended and can increase the risk of low blood sugar.
Considered highly unsafe during pregnancy; a doctor should be consulted for suitable alternatives.
Not recommended while breastfeeding; discuss safer options with your doctor.
May reduce alertness or affect vision, particularly if blood sugar swings too low or too high.
Requires caution in patients with severe kidney disease; dose adjustment may be needed under medical supervision.
Not recommended for patients with liver disease.
Quick tips
- Take the tablet at the same time each day for consistent results
- Never skip a meal after dosing to avoid low blood sugar
- Report unusual swelling, rapid weight gain, or breathlessness to your doctor promptly
- Get liver function and blood sugar checked periodically as advised
- Avoid alcohol while on this medicine
Fact box
| Chemical class | Combination of sulfonylurea, biguanide, and thiazolidinedione |
|---|---|
| Habit forming | No |
| Therapeutic class | Anti Diabetic |
| Action class | Not specified |
Frequently asked questions
What makes Glimestar PM2 different from a two-drug diabetes tablet?
It adds pioglitazone to the glimepiride-metformin combination, giving a third mechanism of action for patients whose sugar levels aren't controlled by dual therapy alone.
Can this tablet be split or crushed?
No, it should be swallowed whole since it is an extended-release tablet; crushing it can affect how the medicine is released in the body.
What side effects should I watch for?
Common effects include headache, sore throat, muscle pain, and sinus-related symptoms. Report any unusual swelling or sudden weight gain to your doctor.
Is this safe for people with liver disease?
No, it is generally not recommended for patients with liver disease. Your doctor will advise on a suitable alternative.
Do I need to follow a special diet with this medicine?
Yes, it works best alongside a diabetes-friendly diet and regular exercise as advised by your doctor.